Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.39 |
| ▸ | KLK1 | P06870 | 3/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28052661 | 0.83 | MEN1 (0.53) | FAAHSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL28272975 | 0.82 | CHKA (0.56) | ATMCHKASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL29390664 | 0.82 | ACKR3 (0.46) | ACKR3ATMKDM1AFAAHALDH1A1 | |
| SCHEMBL16486773 | 0.82 | ACKR3 (0.46) | ACKR3ATMKDM1AFAAHALDH1A1 | |
| SCHEMBL28289204 | 0.80 | KDM4E (0.34) | ATMALDH1A1MEN1KMT2A | |
| SCHEMBL23013506 | 0.80 | ALDH1A1 (0.57) | ACKR3FAAHKLKB1KLK1SMN1; SMN2 | |
| SCHEMBL16486820 | 0.80 | FAAH (0.47) | ACKR3ATMKDM1AFAAHCHKA | |
| SCHEMBL28248650 | 0.80 | KLKB1 (0.46) | ACKR3ATMKDM1AFAAHKLKB1 | |
| SCHEMBL16486396 | 0.78 | CHRM3 (0.50) | ACKR3ATMFAAHKLKB1KLK1 | |
| SCHEMBL27844847 | 0.76 | CHRNB2 (0.54) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683179-A | Inhibitors of plasma kallikrein | 卡尔维斯塔制药有限公司 | 2016-06-15 | — | — | CN | disclosed |