Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 3/20 | 0.34 |
| ▸ | CHUK | O15111 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13504652 | 0.77 | KDM4E (0.37) | KDM4EPARP1SMN1; SMN2CDC7 | |
| SCHEMBL4951717 | 0.76 | SMN1; SMN2 (0.39) | KDM4EPARP1SMN1; SMN2IKBKBCDC7 | |
| SCHEMBL6186161 | 0.76 | PARP1 (0.41) | KDM4EMAPTPARP1SMN1; SMN2 | |
| SCHEMBL28975003 | 0.73 | KDM4E (0.41) | KDM4EMAPTPARP1MEN1KMT2A | |
| SCHEMBL5372889 | 0.72 | KDM4E (0.39) | KDM4EPARP1SMN1; SMN2CDC7 | |
| SCHEMBL3828018 | 0.72 | SMN1; SMN2 (0.39) | KDM4EPARP1SMN1; SMN2IKBKBCDC7 | |
| SCHEMBL27772941 | 0.71 | POLB (0.35) | KDM4EPARP1GAASMN1; SMN2CDC7 | |
| SCHEMBL4852417 | 0.71 | RXRA (0.43) | KDM4ECASP6MAPTMEN1GAA | |
| SCHEMBL10818516 | 0.71 | IKBKB (0.45) | KDM4EMAPTPARP1MEN1GAA | |
| SCHEMBL5033052 | 0.70 | SMN1; SMN2 (0.38) | KDM4EMAPTPARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377837-B | N (heteroaryl) sulfamide derivative as S100 inhibitor | 活跃生物技术有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-105377837-A | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB | 2016-03-02 | — | — | CN | disclosed |