SCHEMBL28054528

SCHEMBL28054528

CC(=O)Cc1cccc([C]=O)c1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.38
CYP2C19 P33261 1/20 0.38
ERCC1 P07992 1/20 0.38
ERCC4 Q92889 1/20 0.38
ALDH1A1 P00352 1/20 0.37
POLB P06746 2/20 0.36
CTBP2 P56545 1/20 0.36
FFAR1 O14842 2/20 0.36
LMNA P02545 1/20 0.36
SLC7A5 Q01650 1/20 0.36
MAPK8 P45983 1/20 0.35
GRIA2 P42262 1/20 0.35
NEK2 P51955 1/20 0.35
GLA P06280 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19369942 0.84 FFAR1 (0.44) CYP1A2CYP2C19ERCC1ERCC4ALDH1A1
SCHEMBL30860058 0.84 ERCC1 (0.52) ERCC1ERCC4FFAR1LMNAMAPK8
SCHEMBL200244 0.84 ERCC1 (0.52) ERCC1ERCC4FFAR1LMNAMAPK8
SCHEMBL6509671 0.82 ALDH1A1 (0.46) CYP1A2CYP2C19ALDH1A1POLBCTBP2
SCHEMBL21997278 0.76 GRIA2 (0.50) ALDH1A1GRIA2
SCHEMBL11450794 0.76 POLB (0.48) ALDH1A1POLBCTBP2FFAR1LMNA
SCHEMBL910601 0.76 MGLL (0.43) CYP1A2ALDH1A1LMNAGLA
SCHEMBL13905068 0.75 BCL2 (0.47) CYP1A2CYP2C19ALDH1A1LMNASLC7A5
SCHEMBL1699683 0.75 CTBP2 (0.59) ALDH1A1POLBCTBP2LMNAMAPK8
SCHEMBL13554933 0.75 ENPP2 (0.44) ALDH1A1POLBCTBP2SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105705017-A Co-crystal and method for producing same 日本曹达株式会社 2016-06-22 CN disclosed