Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27374876 | 0.77 | LMNA (0.35) | LMNAACHEALDH1A1CYP19A1MEN1 | |
| SCHEMBL27866713 | 0.73 | GSK3B (0.32) | LMNACYP19A1 | |
| SCHEMBL27565969 | 0.72 | LMNA (0.31) | LMNA | |
| SCHEMBL6609300 | 0.71 | RAB9A (0.37) | LMNAALDH1A1POLBMAPK1CYP19A1 | |
| SCHEMBL17678405 | 0.69 | KDM4E (0.37) | LMNAALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL27619881 | 0.69 | LMNA (0.35) | LMNAACHEALDH1A1MAPT | |
| SCHEMBL9430732 | 0.65 | GPR35 (0.44) | ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL16212934 | 0.65 | KDM4E (0.49) | LMNAALDH1A1POLBMAPK1SMN1; SMN2 | |
| SCHEMBL28794324 | 0.65 | LMNA (0.35) | LMNAACHEALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL27650991 | 0.65 | KDM4E (0.33) | LMNAALDH1A1CYP19A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105308038-A | Enhancer of zeste homolog 2 inhibitors | GLAXOSMITHKLINE IP NO 2 LTD | 2016-02-03 | — | — | CN | disclosed |