Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | PPOX | P50336 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28256503 | 0.89 | HTT (0.49) | POLBHTTKDM4EHPSEALDH1A1 | |
| SCHEMBL29596381 | 0.89 | HTT (0.49) | POLBHTTKDM4EHPSEALDH1A1 | |
| SCHEMBL30616305 | 0.77 | ALDH1A1 (0.47) | POLBHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28054855 | 0.76 | MEN1 (0.46) | HPSETDP1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28256429 | 0.75 | HPSE (0.64) | KDM4EHPSEALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL28054740 | 0.75 | KMT2A (0.53) | POLBHTTKDM4EHPSEALDH1A1 | |
| SCHEMBL28054738 | 0.75 | HPSE (0.50) | POLBHTTKDM4EHPSEALDH1A1 | |
| SCHEMBL28054674 | 0.73 | ALDH1A1 (0.46) | KDM4EALDH1A1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL28054763 | 0.72 | HSPB1 (0.58) | HTTHPSEALDH1A1TDP1KMT2A | |
| SCHEMBL28625744 | 0.72 | MAPT (0.51) | HTTKDM4EHPSEALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693634-B | Compound and application thereof | 清华大学 | 2018-12-11 | — | — | CN | disclosed |
| CN-105693634-A | Compound and application thereof | 清华大学 | 2016-06-22 | — | — | CN | disclosed |