Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL29071383 | 1.00 | TSHR (0.50) | TSHRACHELMNAMAPK1CYP2D6 | |
| Cadaverine Tartrate SCHEMBL9732307 | 0.85 | LMNA (0.55) | TSHRACHELMNAMAPK1CYP2D6 | |
| Cadaverine Tartrate SCHEMBL18586007 | 0.85 | LMNA (0.55) | TSHRACHELMNAMAPK1CYP2D6 | |
| Toluic Acid SCHEMBL27797922 | 0.85 | ALDH1A1 (0.52) | LMNAHPGDMYCPOLBHIF1A | |
| SCHEMBL15552196 | 0.82 | ACP3 (0.46) | LMNAMAPK1CYP2D6SRCL3MBTL1 | |
| O-Xylene SCHEMBL27483991 | 0.82 | L3MBTL1 (0.38) | TSHRLMNAMAPK1CYP2D6L3MBTL1 | |
| O-Xylene SCHEMBL7498508 | 0.81 | TSHR (0.67) | TSHRACHECES2CES1NPC1 | |
| O-Xylene SCHEMBL28509799 | 0.81 | TSHR (0.67) | TSHRACHECES2CES1NPC1 | |
| Biphenyl SCHEMBL29071567 | 0.79 | TSHR (0.56) | TSHRLMNAMAPK1CYP2D6SRC | |
| Cadaverine Tartrate SCHEMBL28055270 | 0.79 | TSHR (0.56) | TSHRACHELMNACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111971270-B | Dehydration and amination of alpha, beta-dihydroxycarbonyl compounds to alpha amino acids | 阿彻丹尼尔斯米德兰德公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-112074500-B | Dehydration and cleavage of alpha, beta-dihydroxycarbonyl compounds to lactic acid and other products | 阿彻丹尼尔斯米德兰德公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-105492445-B | Compounds (variants) and their use for the treatment of tumor diseases | 国家制药技术有限责任公司 | 2018-02-13 | — | — | CN | disclosed |
| CN-107074807-A | Compositions and methods for inhibiting histone demethylase | 吉利德科学公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-105492445-A | Novel compounds (variants) and their use for the treatment of tumor diseases | LTD LIABILITY COMPANY NAT PHARMACEUTICAL TECH | 2016-04-13 | — | — | CN | disclosed |