Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CEL | P19835 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28056027 | 0.97 | PPM1D (0.47) | PPM1DCELKDM4CKDM4ETBK1 | |
| SCHEMBL28056149 | 0.94 | PPM1D (0.41) | PPM1DTSHRCELFOLH1KDM4C | |
| SCHEMBL2361733 | 0.85 | PPM1D (0.52) | PPM1DCELKDM4CKDM4ETBK1 | |
| SCHEMBL28105519 | 0.84 | PPM1D (0.45) | PPM1DTSHRKDM4EKMT2AALDH1A1 | |
| SCHEMBL19348159 | 0.83 | FOLH1 (0.59) | TSHRFOLH1KMT2AALDH1A1BRS3 | |
| SCHEMBL28048040 | 0.81 | PPM1D (0.48) | PPM1DCELKDM4CKDM4EKMT2A | |
| SCHEMBL27741282 | 0.80 | PPM1D (0.50) | PPM1DCELKDM4CKDM4EKMT2A | |
| SCHEMBL28047118 | 0.78 | KDM4E (0.42) | PPM1DTSHRKDM4EKMT2AALDH1A1 | |
| SCHEMBL5051198 | 0.77 | FOLH1 (0.65) | TSHRFOLH1KDM4EGAA | |
| Cyclopropane SCHEMBL28174238 | 0.76 | RXRA (0.48) | TSHRFOLH1KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105407888-A | Novel bicyclic bromodomain inhibitors | ZENITH EPIGENETICS CORP | 2016-03-16 | — | — | CN | claimed |
| CN-105407888-A | Novel bicyclic bromodomain inhibitors | ZENITH EPIGENETICS CORP | 2016-03-16 | — | — | CN | disclosed |