Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 7/20 | 0.36 |
| ▸ | CFTR | P13569 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28057781 | 0.86 | CFTR (0.45) | ABCC9ABCC8KCNJ11KCNJ8IKBKB | |
| SCHEMBL28157273 | 0.81 | ABCC9 (0.39) | ABCC9ABCC8KCNJ11KCNJ8IKBKB | |
| SCHEMBL28057794 | 0.68 | MEN1 (0.47) | CFTRMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL28156822 | 0.67 | CFTR (0.32) | CFTRKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL28156746 | 0.67 | CFTR (0.40) | ABCC9ABCC8KCNJ11KCNJ8IKBKB | |
| SCHEMBL16338571 | 0.66 | CFTR (0.78) | ABCC9ABCC8KCNJ11KCNJ8IKBKB | |
| SCHEMBL28057649 | 0.64 | LMNA (0.39) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL775608 | 0.63 | HTR2C (0.59) | ABCC9ABCC8KCNJ11KCNJ8HTR6 | |
| SCHEMBL16246497 | 0.61 | ANXA2 (0.41) | IKBKBHTR6KDM4EMEN1ALDH1A1 | |
| SCHEMBL16246531 | 0.61 | ALDH1A1 (0.52) | IKBKBHTR6KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-A | Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis | GALAPAGOS NV | 2016-04-27 | — | — | CN | disclosed |