Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28156735 | 0.81 | HDAC4 (0.43) | MEN1KMT2AHDAC4HDAC6ALDH1A1 | |
| SCHEMBL28057781 | 0.69 | CFTR (0.45) | MEN1KMT2AALDH1A1MAPTCFTR | |
| SCHEMBL28057682 | 0.68 | ABCC9 (0.39) | MEN1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL16338655 | 0.67 | CFTR (0.67) | MEN1KMT2AHDAC4HDAC6ALDH1A1 | |
| SCHEMBL4778320 | 0.66 | KMT2A (0.47) | MEN1KMT2AHDAC4HDAC6ALDH1A1 | |
| SCHEMBL1135577 | 0.65 | LMNA (0.46) | MEN1KMT2AHDAC4HDAC6ALDH1A1 | |
| SCHEMBL12261100 | 0.65 | KMT2A (0.52) | MEN1KMT2AHDAC4HDAC6ALDH1A1 | |
| SCHEMBL4876765 | 0.64 | KMT2A (0.52) | MEN1KMT2AHDAC4HDAC6ALDH1A1 | |
| SCHEMBL18080771 | 0.64 | KMT2A (0.62) | MEN1KMT2AHDAC4HDAC6ALDH1A1 | |
| SCHEMBL28057649 | 0.64 | LMNA (0.39) | MEN1KMT2AALDH1A1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-A | Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis | GALAPAGOS NV | 2016-04-27 | — | — | CN | disclosed |