Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | ADK | P55263 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PDE11A | Q9HCR9 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28057759 | 0.85 | EGFR (0.53) | EGFRSRCADKLMNATP53 | |
| SCHEMBL22032001 | 0.78 | SRC (0.50) | EGFRSRCADKLMNAPDE11A | |
| SCHEMBL16236616 | 0.78 | SRC (0.50) | EGFRSRCADK | |
| SCHEMBL29484487 | 0.78 | SRC (0.50) | EGFRSRCADK | |
| SCHEMBL25388583 | 0.74 | YTHDC1 (0.49) | EGFRSRCADKLMNATP53 | |
| SCHEMBL29588944 | 0.71 | ADK (0.45) | EGFRSRCADKYTHDC1PDE2A | |
| SCHEMBL17818402 | 0.71 | ADK (0.45) | EGFRSRCADKYTHDC1PIK3CD | |
| SCHEMBL27890208 | 0.69 | ADK (0.55) | EGFRSRCADKYTHDC1 | |
| SCHEMBL30813639 | 0.68 | PDPK1 (0.33) | LMNAGRM1 | |
| SCHEMBL22086072 | 0.68 | SRC (0.53) | SRCLMNATP53MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431436-A | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2016-03-23 | — | — | CN | disclosed |