Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28058293 | 0.75 | HPGDS (0.35) | HPGDSNNMTCYP11B1CYP11B2 | |
| SCHEMBL17755580 | 0.73 | HPGDS (0.39) | HPGDSNNMTCYP11B1CYP11B2 | |
| SCHEMBL28202769 | 0.72 | MAPT (0.36) | — | |
| SCHEMBL28202150 | 0.70 | HPGDS (0.40) | HPGDSNNMT | |
| SCHEMBL16432565 | 0.70 | HPGDS (0.40) | HPGDSNNMT | |
| SCHEMBL28058298 | 0.69 | CYP11B1 (0.37) | HPGDSCYP11B1CYP11B2 | |
| SCHEMBL18783466 | 0.69 | MKNK1 (0.40) | HPGDSNNMTCYP11B1CYP11B2 | |
| SCHEMBL16438181 | 0.67 | ALPL (0.42) | HPGDSNNMT | |
| SCHEMBL16429909 | 0.65 | HPGDS (0.45) | HPGDSNNMTCYP11B1CYP11B2 | |
| SCHEMBL16432321 | 0.65 | HTR5A (0.43) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473568-A | 1, 7-naphthyridine derivatives | HOFFMANN LA ROCHE | 2016-04-06 | — | — | CN | disclosed |