Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | STAMBP | O95630 | 1/20 | 0.31 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16438181 | 0.75 | ALPL (0.42) | HPGDSNNMTDYRK1ASIRT2SIRT1 | |
| SCHEMBL840723 | 0.75 | NNMT (0.36) | HPGDSNNMTSMN1; SMN2PSMD14STAMBP | |
| SCHEMBL28058331 | 0.75 | HPGDS (0.33) | HPGDSNNMTCYP11B1CYP11B2 | |
| SCHEMBL17755580 | 0.73 | HPGDS (0.39) | HPGDSNNMTSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL28202150 | 0.73 | HPGDS (0.40) | HPGDSNNMTSMN1; SMN2MAP4K4PSMD14 | |
| SCHEMBL16432565 | 0.73 | HPGDS (0.40) | HPGDSNNMTSMN1; SMN2MAP4K4PSMD14 | |
| SCHEMBL18783466 | 0.72 | MKNK1 (0.40) | HPGDSNNMTSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL28202151 | 0.71 | IKBKB (0.34) | CDK2IKBKBROCK2JAK1TYK2 | |
| SCHEMBL28229692 | 0.71 | CYP11B2 (0.45) | CYP11B1CYP11B2KDM4EMKNK1MKNK2 | |
| SCHEMBL16432422 | 0.71 | MAP4K4 (0.44) | CDK1PIM1CDK2MAPKAPK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473568-B | 1, 7-naphthyridine derivatives | 豪夫迈·罗氏有限公司 | 2018-02-13 | — | — | CN | disclosed |
| CN-105473568-A | 1, 7-naphthyridine derivatives | HOFFMANN LA ROCHE | 2016-04-06 | — | — | CN | disclosed |