Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18228033 | 0.98 | ACHE (0.47) | MAPK8CDC7ACHECCNT1CCNA2 | |
| SCHEMBL28059058 | 0.94 | DYRK1A (0.44) | MAPK8CDC7ACHECCNT1CCNA2 | |
| SCHEMBL11113279 | 0.81 | ACHE (0.51) | ACHECCNT1CCNA2CDK2CDK9 | |
| SCHEMBL11113633 | 0.81 | ADRB1 (0.61) | ACHESMN1; SMN2ALDH1A1ADRB1KDM4E | |
| SCHEMBL5525967 | 0.81 | PIK3CA (0.58) | ACHECCNT1CCNA2CDK2CDK9 | |
| SCHEMBL30635502 | 0.80 | GBA1 (0.55) | MAPK8CDC7ACHECCNT1CCNA2 | |
| SCHEMBL27941842 | 0.80 | GBA1 (0.55) | MAPK8CDC7ACHECCNT1CCNA2 | |
| SCHEMBL12597157 | 0.78 | KDM4E (0.55) | ACHEPOLBSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL7019990 | 0.78 | ACHE (0.45) | MAPK8CDC7ACHECCNT1CCNA2 | |
| SCHEMBL9900073 | 0.78 | KDM1A (0.47) | MAPK8CDC7ACHECCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250084054-A1 | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION | JNANA THERAPEUTICS INC. | 2025-03-13 | — | — | US | disclosed |
| CN-105814051-B | Tetrahydroimidazopyridine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-09-25 | — | — | CN | disclosed |
| CN-107787319-A | Indazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2018-03-09 | — | — | CN | disclosed |
| CN-104470924-B | Imidazopyrazines derivant as TNF active regulator | UCB生物制药私人有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105814041-A | Benzotriazole derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814056-A | Purine derivatives as modulators of TNF activity | UCB生物制药私人有限公司 | 2016-07-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250084054-A1 | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION | SLC18A2, SLC6A19, SLC1A1 | MAPK8 3748/4885CDC7 2669/4885ACHE 4763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.