Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | RBP4 | P02753 | 2/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28789641 | 0.86 | ALDH1A1 (0.38) | MEN1KMT2AHTR6CYP1A2CYP3A4 | |
| SCHEMBL2334032 | 0.83 | STS (0.48) | MAPTGPR119SMN1; SMN2 | |
| SCHEMBL2364532 | 0.81 | MEN1 (0.43) | HCRTR2MEN1KMT2ARBP4SLC6A2 | |
| SCHEMBL27821349 | 0.74 | SLC6A2 (0.37) | MEN1KMT2ARBP4HTR6SLC6A2 | |
| SCHEMBL28298593 | 0.74 | MEN1 (0.59) | MEN1KMT2AMAPT | |
| SCHEMBL22524566 | 0.73 | STS (0.49) | MAPTGPR119SMN1; SMN2 | |
| SCHEMBL27811329 | 0.72 | RBP4 (0.48) | HCRTR2MEN1KMT2ARBP4SMN1; SMN2 | |
| SCHEMBL14639250 | 0.72 | ELANE (0.50) | MAPT | |
| SCHEMBL27488566 | 0.72 | RIPK1 (0.51) | — | |
| SCHEMBL15434568 | 0.72 | KDM4E (0.41) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109640989-A | Compounds for the treatment of neurogenic orthostatic hypotension | 施万生物制药研发IP有限责任公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-102209712-B | Process for preparing 4- [2- (2-fluorophenoxymethyl) phenyl ] piperidine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-04-06 | — | — | CN | disclosed |