Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838102 | 0.92 | PREP (0.37) | PREPUSP2SMN1; SMN2NR1H2CHRM2 | |
| SCHEMBL28856336 | 0.90 | CHRM2 (0.38) | PREPUSP2SMN1; SMN2NR1H2CHRM2 | |
| Hydrochloric Acid SCHEMBL28241841 | 0.90 | PREP (0.36) | PREPUSP2SMN1; SMN2NR1H2CHRM2 | |
| SCHEMBL29552182 | 0.88 | PREP (0.34) | PREPNR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL28222533 | 0.87 | MAPK1 (0.35) | PREPMAPK1USP2SMN1; SMN2NR1H2 | |
| SCHEMBL28223429 | 0.87 | SIGMAR1 (0.32) | MAPK1USP2SMN1; SMN2NR1H2 | |
| SCHEMBL28099175 | 0.86 | CHRM2 (0.31) | PREPCHRM2CHRM1CHRM3 | |
| SCHEMBL28113304 | 0.86 | SIGMAR1 (0.32) | MAPK1NR1H2 | |
| Pyrrole SCHEMBL28865869 | 0.85 | GPR119 (0.32) | PREPMAPK1USP2SMN1; SMN2NR1H2 | |
| SCHEMBL28110993 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104892582-B | Azetidine as the mek inhibitor for treating proliferative disease | 埃克塞利希斯股份有限公司 | 2019-09-27 | — | — | CN | claimed |
| CN-106458939-B | * oxazolidinyl compound and the selective androgen receptor agonist comprising the compound | 东亚ST株式会社 | 2019-05-17 | — | — | CN | claimed |
| CN-106841544-A | A kind of purple potato pears compound fruit vinegar sample determination system and its method of work based on Plasma MIG controls | 徐州工程学院 | 2017-06-13 | — | — | CN | claimed |
| CN-106458939-A | Oxazolidine-based compound and selective androgen receptor agonist comprising same | 东亚ST株式会社 | 2017-02-22 | — | — | CN | claimed |
| CN-104892582-B | Azetidine as the mek inhibitor for treating proliferative disease | 埃克塞利希斯股份有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-110191882-A | Novel heterocyclic compounds, preparation method and the pharmaceutical composition comprising it | 株式会社大熊制药 | 2019-08-30 | — | — | CN | disclosed |
| CN-106061973-B | Pyrrolo [2,3-D ] pyrimidinyl, pyrrolo [2,3-B ] pyrazinyl and pyrrolo [2,3-D ] pyridylacrylamide | 辉瑞公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-105899491-B | 1-pyridazine-/triazin-3-yl-piperazine (-oxazine)/pyridine/pyrrolidine derivatives and compositions thereof for inhibiting SHP2 activity | 诺华股份有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109415381-A | Thiazolopyridine derivatives as GPR119 agonist | 人类制药有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109071455-A | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | 科尔沃斯制药股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108473495-A | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-107922347-A | New imide derivative and its purposes as medicine | 田边三菱制药株式会社 | 2018-04-17 | — | — | CN | disclosed |
| CN-105143222-B | Glycosidase inhibitor | 默克专利有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-107417684-A | Heterocyclic acryloyloxy amine | 辉瑞公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-104817561-B | The Piperidine inhibitors of JAK3 | 奥斯拜客斯制药有限公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-106841544-A | A kind of purple potato pears compound fruit vinegar sample determination system and its method of work based on Plasma MIG controls | 徐州工程学院 | 2017-06-13 | — | — | CN | disclosed |
| CN-104447740-B | Imidazolone derivative as well as drug composition and application thereof | 北京富龙康泰生物技术有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106061973-A | Pyrrolo [2,3-D ] pyrimidinyl, pyrrolo [2,3-B ] pyrazinyl and pyrrolo [2,3-D ] pyridylacrylamide | 辉瑞公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-102216291-B | Carbamate derivatives containing alkyl-heterocycles, preparation and therapeutic use thereof | 赛诺菲-安万特 | 2016-08-03 | — | — | CN | disclosed |