Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 6/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374802 | 0.76 | P2RX7 (0.51) | F7F3P2RX7 | |
| SCHEMBL28625449 | 0.75 | KDM4E (0.44) | AURKATPX2F7F3PRKAB2 | |
| SCHEMBL15797442 | 0.73 | P2RX7 (0.51) | AURKATPX2F7F3PRKAB2 | |
| SCHEMBL31342218 | 0.73 | KDM4E (0.45) | AURKATPX2F7F3XDH | |
| SCHEMBL13947815 | 0.71 | AURKA (0.48) | AURKATPX2F7F3PRKAB2 | |
| SCHEMBL15822895 | 0.71 | P2RX7 (0.54) | AURKATPX2F7F3PRKAB2 | |
| SCHEMBL15797418 | 0.70 | P2RX7 (0.52) | AURKATPX2F7F3PRKAB2 | |
| SCHEMBL29047547 | 0.70 | AURKA (0.40) | AURKATPX2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2806054 | 0.69 | AURKA (0.56) | AURKATPX2F7F3PRKAB2 | |
| SCHEMBL30446838 | 0.69 | AURKA (0.56) | AURKATPX2F7F3PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975252-B2 | Morpholine derivative | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-03-10 | — | — | US | disclosed |
| CN-101679324-B | Morpholine derivatives | MITSUBISHI TANABE PHARMA CORP | 2012-10-03 | — | — | CN | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
| CN-101679324-A | Morpholine derivatives | MITSUBISHI TANABE PHARMA CORP | 2010-03-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | REN, AGTR1, AGTR2 | AURKA 1249/4885TPX2 4513/4885F7 788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.