Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28018573 | 0.84 | KDM4E (0.52) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL28060867 | 0.81 | PDK1 (0.39) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL28053391 | 0.81 | POLB (0.42) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL28832949 | 0.76 | PDK1 (0.51) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL1779793 | 0.73 | PDK1 (0.46) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL28829583 | 0.73 | CA12 (0.38) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL2093872 | 0.73 | KMT2A (0.47) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL1012748 | 0.73 | KMT2A (0.49) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL27775487 | 0.73 | NR3C1 (0.51) | KDM4EKMT2AMEN1MAPTHTT | |
| SCHEMBL20984511 | 0.72 | GAA (0.52) | KDM4ELMNAKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492377-B | As the triazolopyridine compounds of PIM kinase inhibitor | ARRAY BIOPHARMA INC. (US) | 2016-04-20 | — | — | CN | disclosed |