Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422388 | 0.83 | TSHR (0.50) | TSHRSMN1; SMN2HSD17B10HSPB1TDP1 | |
| SCHEMBL16335619 | 0.77 | MAPT (0.50) | TSHRSMN1; SMN2TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL423843 | 0.76 | ALDH1A1 (0.56) | TSHRHSD17B10TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL10422347 | 0.74 | TSHR (0.60) | TSHRSMN1; SMN2HSD17B10HSPB1TDP1 | |
| SCHEMBL3029646 | 0.73 | MAPT (0.56) | TSHRSMN1; SMN2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL28054673 | 0.73 | TSHR (0.49) | TSHRSMN1; SMN2HSD17B10TDP1ALDH1A1 | |
| SCHEMBL28078625 | 0.72 | PDK1 (0.47) | TSHRSMN1; SMN2TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL16952275 | 0.72 | MAPT (0.57) | SMN1; SMN2TDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL3030569 | 0.71 | ALDH1A1 (0.53) | TSHRHSPB1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL11592413 | 0.71 | ALDH1A1 (0.39) | TSHRSMN1; SMN2TDP1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531273-A | Bromodomain inhibitors | ABBVIE INC | 2016-04-27 | — | — | CN | disclosed |
| CN-105518007-A | BROMODOMAIN INHIBITORS | ABBVIE INC | 2016-04-20 | — | — | CN | disclosed |