Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18701256 | 0.71 | MAPT (0.45) | ALDH1A1LMNAGRIA4GRIA2ALOX15 | |
| SCHEMBL10970573 | 0.70 | — | — | |
| SCHEMBL28352941 | 0.69 | ALDH1A1 (0.41) | ALDH1A1LMNAGRIA4GRIA2HSD17B10 | |
| SCHEMBL28549036 | 0.67 | ALDH1A1 (0.46) | ALDH1A1LMNAGRIA4GRIA2KDM4E | |
| SCHEMBL14193672 | 0.67 | ALDH1A1 (0.76) | ALDH1A1LMNAGRIA4GRIA2HSD17B10 | |
| SCHEMBL18701285 | 0.66 | MAPT (0.41) | LMNAGRIA4GRIA2ALOX15HTT | |
| SCHEMBL279720 | 0.66 | GRIA2 (0.40) | ALDH1A1LMNAGRIA4GRIA2HTT | |
| SCHEMBL11429710 | 0.65 | LMNA (0.58) | ALDH1A1LMNAGRIA4GRIA2HSD17B10 | |
| SCHEMBL7834754 | 0.65 | ALDH1A1 (0.63) | ALDH1A1LMNAGRIA4GRIA2HSD17B10 | |
| SCHEMBL27400436 | 0.64 | BRD4 (0.44) | ALDH1A1LMNAHSD17B10ADRA2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105431422-B | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2019-08-30 | — | — | CN | disclosed |
| CN-105408321-B | Indoles and azole derivatives, their preparation method and the pharmaceutical composition containing them | 法国施维雅药厂 | 2019-03-08 | — | — | CN | disclosed |
| CN-105408321-A | Novel derivatives of indole and pyrrole, method for the production thereof and pharmaceutical compositions containing same | SERVIER LAB | 2016-03-16 | — | — | CN | disclosed |