Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28154615 | 0.81 | RAPGEF4 (0.67) | RAPGEF4CYP2C9CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL11200612 | 0.81 | RAPGEF4 (1.00) | RAPGEF4CYP2C9CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL27986845 | 0.77 | NPBWR1 (0.41) | CYP2C9CYP2C19ALDH1A1CYP3A4FFAR4 | |
| SCHEMBL28091556 | 0.75 | FFAR4 (0.36) | RAPGEF4ALDH1A1FFAR4GABRG2GABRB3 | |
| SCHEMBL28061531 | 0.74 | PTGS1 (0.38) | ALDH1A1FFAR4GABRG2GABRB3GABRA3 | |
| SCHEMBL911097 | 0.74 | TAAR1 (0.55) | ALDH1A1CYP3A4 | |
| SCHEMBL6539948 | 0.71 | PKM (0.68) | RAPGEF4ALDH1A1CYP3A4PKMGAA | |
| SCHEMBL28091696 | 0.71 | RAPGEF4 (0.64) | RAPGEF4CYP2C9CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL14992753 | 0.70 | PKM (0.56) | RAPGEF4CYP2C9CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL15417550 | 0.70 | PKM (0.72) | RAPGEF4CYP2C9CYP2C19ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105906617-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-104254534-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-105906617-A | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-103038231-B | Modulators of HEC1 activity and methods thereof | Taivex Therapeutics Corp. (CN) | 2016-04-20 | — | — | CN | disclosed |