Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.67 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28063981 | 0.81 | SCN8A (0.69) | SCN8ASCN10APOLBMEN1KMT2A | |
| SCHEMBL28064012 | 0.81 | SCN8A (0.67) | SCN8ASCN10AHTTTP53MAPT | |
| SCHEMBL29970845 | 0.81 | CHRNB2 (0.78) | HTTTP53CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL29201497 | 0.81 | CHRNB2 (0.78) | HTTTP53CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL15561778 | 0.80 | SCN8A (1.00) | SCN8ASCN10AMEN1KMT2A | |
| SCHEMBL28827912 | 0.73 | P4HTM (0.70) | HTTTP53CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6300626 | 0.73 | HTT (0.72) | HTTTP53CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL974404 | 0.73 | SLC6A3 (0.63) | HTTTP53CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11186905 | 0.72 | HTT (0.83) | HTTTP53CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6053692 | 0.72 | CYP2C9 (0.78) | CHRNB2CHRNB4CHRNA3CHRNA4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473554-A | Fused piperidine amides as modulators of ion channels | VERTEX PHARMA | 2016-04-06 | — | — | CN | disclosed |