Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 16/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 15/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19415141 | 0.79 | KMT2A (0.47) | FEN1ALOX5APKMT2A | |
| SCHEMBL15916605 | 0.79 | TDP1 (0.44) | FEN1ALOX5APCOMT | |
| SCHEMBL7417140 | 0.78 | FEN1 (0.43) | FEN1ALOX5APKMT2ACOMT | |
| SCHEMBL9955204 | 0.77 | PARP1 (0.45) | FEN1ALOX5APKMT2ACOMT | |
| SCHEMBL10936188 | 0.77 | KMT2A (0.68) | KMT2A | |
| SCHEMBL30068387 | 0.75 | COMT (0.46) | FEN1ALOX5APCOMT | |
| SCHEMBL27172049 | 0.75 | COMT (0.46) | FEN1ALOX5APCOMT | |
| SCHEMBL390770 | 0.75 | KMT2A (0.56) | KMT2A | |
| SCHEMBL28064627 | 0.73 | MEN1 (0.57) | KMT2A | |
| SCHEMBL1491207 | 0.73 | KMT2A (0.54) | KMT2ACOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642838-B | EGFR inhibitor and preparation and application thereof | 江苏威凯尔医药科技有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-110642838-A | EGFR inhibitor and preparation and application thereof | 江苏威凯尔医药科技有限公司 | 2020-01-03 | — | — | CN | disclosed |
| CN-105503827-A | EGFR (Epidermal growth factor receptor) inhibitor and preparation method and use thereof | SHANGHAI HANSOH BIOMEDICAL CO LTD | 2016-04-20 | — | — | CN | disclosed |