SCHEMBL390770

SCHEMBL390770

Nc1cccnc1S(N)(=O)=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.56
CA1 P00915 5/20 0.49
CA2 P00918 5/20 0.49
CA9 Q16790 5/20 0.49
CA12 O43570 4/20 0.49
CYP2C9 P11712 2/20 0.45
CA4 P22748 2/20 0.45
CA6 P23280 2/20 0.45
CA5A P35218 2/20 0.45
CA7 P43166 2/20 0.45
CA14 Q9ULX7 2/20 0.45
CA5B Q9Y2D0 1/20 0.45
MAPK1 P28482 1/20 0.44
FTO Q9C0B1 1/20 0.41
MEN1 O00255 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
NFKBIA P25963 1/20 0.37
RELA Q04206 1/20 0.37
SLC40A1 Q9NP59 1/20 0.37
HSP90AA1 P07900 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10936188 0.84 KMT2A (0.68) KMT2ACA1CA2CA9CA12
SCHEMBL18230355 0.81 KMT2A (0.59) KMT2ACA1CA2CA9CA12
SCHEMBL8517377 0.81 KMT2A (0.54) KMT2ACA1CA2CA9CA12
SCHEMBL1491207 0.81 KMT2A (0.54) KMT2ACA1CA2CA9CA12
SCHEMBL30908297 0.81 KMT2A (0.59) KMT2ACA1CA2CA9CA12
SCHEMBL8537341 0.78 FTO (0.49) KMT2ACA1CA2CA9CA12
SCHEMBL10480797 0.78 CA1 (0.58) KMT2ACA1CA2CA9CA12
SCHEMBL14120534 0.78 CA2 (0.45) KMT2ACA1CA2CA9CA12
SCHEMBL21061787 0.78 KMT2A (0.56) KMT2ACA1CA2CA9CA12
SCHEMBL8885016 0.77 CA1 (0.43) KMT2ACA1CA2CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3670490-B1 METHOD OF PURIFYING PINE CHEMICAL COMPOSITIONS FROM ALDEHYDES KRATON POLYMERS LLC (US) 2023-01-18 EP claimed
EP-3670490-A1 METHOD OF PURIFYING PINE CHEMICAL COMPOSITIONS FROM ALDEHYDES Kraton Polymers LLC (US) 2020-06-24 EP claimed
US-20200165191-A1 Method of Purifying Pine Chemical Compositions from Aldehydes KRATON POLYMERS LLC (US) 2020-05-28 US claimed
EP-3670490-B1 METHOD OF PURIFYING PINE CHEMICAL COMPOSITIONS FROM ALDEHYDES KRATON POLYMERS LLC (US) 2023-01-18 EP disclosed
CN-115611897-A Compounds as RSK2 inhibitors and uses thereof 南京圣和药业股份有限公司 2023-01-17 CN disclosed
US-20210380548-A1 Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family CTXT PTY LIMITED (AU) 2021-12-09 US disclosed
US-20210380548-A1 Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family CTXT PTY LIMITED (AU) 2021-12-09 US disclosed
US-10822302-B2 Method of purifying pine chemical compositions from aldehydes KRATON POLYMERS LLC (US) 2020-11-03 US disclosed
EP-3676266-A1 FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY Ctxt Pty Ltd (AU) 2020-07-08 EP disclosed
EP-3670490-A1 METHOD OF PURIFYING PINE CHEMICAL COMPOSITIONS FROM ALDEHYDES Kraton Polymers LLC (US) 2020-06-24 EP disclosed
US-20200165191-A1 Method of Purifying Pine Chemical Compositions from Aldehydes KRATON POLYMERS LLC (US) 2020-05-28 US disclosed
US-5459138-A Dysfunctions of glutamatergic neurotransmission associated with learning and memory ADIR ET COMPAGNIE (FR) 1995-10-17 US disclosed
US-5410063-A Pyridin-2-yl-sulfonamides useful for the preparation of herbicidally active sulfonylureas CIBA-GEIGY CORPORATION (US) 1995-04-25 US disclosed
EP-0618209-A1 Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1994-10-05 EP disclosed
US-5352654-A Pre- and post-emergence herbicides, plant growth regulators CIBA-GEIGY CORPORATION (US) 1994-10-04 US disclosed
EP-0402316-B1 Sulphonylureas CIBA GEIGY AG (CH) 1994-09-14 EP disclosed
US-5336773-A Herbicides; plant growth regulators CIBA-GEIGY CORPORATION (US) 1994-08-09 US disclosed
US-5221315-A Herbicides and plant growth regulators CIBA-GEIGY CORPORATION (US) 1993-06-22 US disclosed
EP-0459949-A1 Sulfonyl ureas with herbicidal activity and useful as plant growth regulators CIBA-GEIGY AG (CH) 1991-12-04 EP disclosed
EP-0402316-A1 Sulphonylureas CIBA-GEIGY AG (CH) 1990-12-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210380548-A1 Fused [1,2,4]Thiadiazine Derivatives Which Act as KAT Inhibitors of the MYST Family KAT5, KAT6A, KAT2A KMT2A 86/4885CA1 3478/4885CA2 4004/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.