Coumarin

Coumarin

SCHEMBL28065272

CC(=O)CCc1ccc([N+](=O)[O-])cc1.O=c1ccc2ccccc2o1

nearest known ligand 0.47

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.47
CA12 O43570 2/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA3 P07451 2/20 0.47
CA4 P22748 2/20 0.47
CA5A P35218 2/20 0.47
CA7 P43166 2/20 0.47
CA9 Q16790 2/20 0.47
CA14 Q9ULX7 2/20 0.47
CA5B Q9Y2D0 2/20 0.47
CA6 P23280 1/20 0.47
MCL1 Q07820 1/20 0.47
SOST Q9BQB4 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
MAPT P10636 4/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
PSMD14 O00487 1/20 0.44
TLR9 Q9NR96 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzylacetone SCHEMBL28065327 0.85 ALDH1A1 (0.60) LMNACA12CA1CA2CA3
SCHEMBL8855273 0.79 TSHR (0.61) LMNAMAPTMEN1KMT2AALDH1A1
Benzylacetone SCHEMBL27649654 0.75 ALDH1A1 (0.70) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL1491019 0.74 CA9 (0.62) LMNACA12CA1CA2CA3
Coumarin SCHEMBL21708094 0.73 CA12 (0.74) LMNACA12CA1CA2CA3
Coumarin SCHEMBL27598031 0.73 CA9 (0.80) LMNACA12CA1CA2CA3
Coumarin SCHEMBL314829 0.72 CA9 (0.77) LMNACA12CA1CA2CA3
SCHEMBL8934569 0.71 TSHR (0.58) MAPTMEN1KMT2AALDH1A1HTT
Coumarin SCHEMBL11466859 0.70 CA12 (0.80) LMNACA12CA1CA2CA3
Coumarin SCHEMBL11101317 0.70 CA12 (0.87) LMNACA12CA1CA2CA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103965150-B Scopoletin derivant and its preparation method and application 广州康臣药物研究有限公司 2016-06-15 CN disclosed