Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | MPI | P34949 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.55 |
| ▸ | ESR1 | P03372 | 7/20 | 0.55 |
| ▸ | PKLR | P30613 | 1/20 | 0.54 |
| ▸ | GALNT2 | Q10471 | 1/20 | 0.54 |
| ▸ | GALNT1 | Q10472 | 1/20 | 0.54 |
| ▸ | GALNT3 | Q14435 | 1/20 | 0.54 |
| ▸ | GALNT10 | Q86SR1 | 1/20 | 0.54 |
| ▸ | GALNT13 | Q8IUC8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824164 | 0.88 | KDM4E (0.66) | KDM4EGAAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL15285080 | 0.86 | KDM4E (0.61) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL31414410 | 0.86 | KDM4E (0.61) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL28065536 | 0.80 | KDM4E (0.79) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL28065504 | 0.80 | ESR2 (0.56) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL10794106 | 0.80 | HSD17B3 (0.50) | KDM4EGAAHTTSMN1; SMN2ESR2 | |
| SCHEMBL19236367 | 0.79 | KDM4E (0.79) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL14756048 | 0.78 | KDM4E (0.53) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL8745765 | 0.75 | KDM4E (0.65) | KDM4EGAAMAPTMAPK1MCL1 | |
| SCHEMBL2791744 | 0.74 | GAA (0.67) | KDM4EGAAMAPTMAPK1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524034-B | Preparation, pharmacological action and the application for treating cerebral ischemia of coumarin derivative | 北京大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-105566269-B | Preparation, pharmacological action and the application for treating itch of coumarin derivative | 北京大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-105566269-A | Preparation and pharmacological effects of coumarin derivative and application of coumarin derivative to treatment on pruritus | UNIV BEIJING | 2016-05-11 | — | — | CN | disclosed |
| CN-105524034-A | Preparation method of coumarin derivative, pharmacological effect of coumarin derivative and use of coumarin derivative in treatment on cerebral ischemia | UNIV BEIJING | 2016-04-27 | — | — | CN | disclosed |