SCHEMBL28065982

SCHEMBL28065982

CC(C)(C)C(=O)CC(CN)c1ccc(Br)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABBR2 O75899 4/20 0.45
GABBR1 Q9UBS5 4/20 0.45
LMNA P02545 2/20 0.45
CYP2C9 P11712 2/20 0.45
CYP1A2 P05177 2/20 0.45
CYP3A4 P08684 1/20 0.45
ADORA3 P0DMS8 1/20 0.45
NFKB1 P19838 1/20 0.45
DRD3 P35462 1/20 0.45
BLM P54132 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C19 P33261 1/20 0.45
MEN1 O00255 1/20 0.45
THRB P10828 1/20 0.45
TSHR P16473 1/20 0.45
KMT2A Q03164 1/20 0.45
ALOX5 P09917 1/20 0.41
HTR2A P28223 1/20 0.40
MME P08473 1/20 0.38
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5877648 0.80 GABBR2 (0.42) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL5877532 0.80 GABBR2 (0.42) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL5877614 0.80 GABBR2 (0.42) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL23731633 0.77 MEN1 (0.45) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL28065966 0.77 ACHE (0.46) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL11079558 0.74 HTR2A (0.58) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL12193938 0.73 HTR2A (0.42) LMNACYP1A2MEN1KMT2AALOX5
Hydrochloric Acid SCHEMBL1866896 0.72 HTR2A (0.56) GABBR2GABBR1LMNACYP2C9CYP1A2
SCHEMBL11084494 0.70 ALOX5 (0.46) CYP1A2CYP2D6MEN1KMT2AALOX5
SCHEMBL17968651 0.69 ALDH1A1 (0.38) LMNACYP1A2CYP3A4ADORA3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105461578-A Synthesis method for 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone UNIV CHANGZHOU 2016-04-06 CN claimed
CN-105461578-A Synthesis method for 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone UNIV CHANGZHOU 2016-04-06 CN disclosed
CN-105461578-A Synthesis method for 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone UNIV CHANGZHOU 2016-04-06 CN disclosed
CN-105461578-A Synthesis method for 2,2-dimethyl-5-(4-bromophenyl)-6-amino-3-hexanone UNIV CHANGZHOU 2016-04-06 CN disclosed