Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.45 |
| ▸ | XDH | P47989 | 10/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28491140 | 0.77 | NR1H2 (0.46) | CYP11B2 | |
| SCHEMBL17185601 | 0.72 | FTO (0.56) | MKNK1MKNK2XDHSLC22A12TSHR | |
| SCHEMBL748667 | 0.72 | CYP11B2 (0.50) | CYP11B2SLC22A12CASP1MAP4K4 | |
| SCHEMBL2770320 | 0.72 | TSHR (0.68) | MKNK1MKNK2XDHTSHRCASP1 | |
| SCHEMBL17187979 | 0.70 | CYP11B1 (0.46) | CYP11B2MKNK1MKNK2XDHSLC22A12 | |
| SCHEMBL17188036 | 0.69 | ACMSD (0.46) | CYP11B2MKNK1MKNK2XDHSLC22A12 | |
| SCHEMBL14779956 | 0.68 | CYP11B2 (0.58) | CYP11B2 | |
| SCHEMBL16150971 | 0.68 | MAPT (0.52) | XDHSLC22A12 | |
| SCHEMBL3104322 | 0.68 | XDH (0.57) | MKNK1MKNK2XDHTSHRCASP1 | |
| SCHEMBL21239978 | 0.68 | XDH (0.50) | MKNK1MKNK2XDHSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112521369-A | Compounds and compositions for inhibition of FASN | 福马治疗股份有限公司 | 2021-03-19 | — | — | CN | disclosed |
| CN-105492008-B | Compounds and compositions for inhibition of FASN | 福马治疗股份有限公司 | 2020-11-27 | — | — | CN | disclosed |
| CN-105492008-A | Novel compounds and compositions for inhibition of fasn | FORMA THERAPEUTICS INC | 2016-04-13 | — | — | CN | disclosed |