SCHEMBL28068259

SCHEMBL28068259

CCOC(=O)c1cc(-c2ccc(C(=O)OC)cc2)c2ccccc2c1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.50
ALOX5 P09917 1/20 0.47
F2RL3 Q96RI0 1/20 0.46
TNKS O95271 2/20 0.46
MAPT P10636 2/20 0.45
TSHR P16473 1/20 0.45
TP53 P04637 1/20 0.45
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 2/20 0.45
GAA P10253 2/20 0.45
HPGD P15428 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
GPR84 Q9NQS5 1/20 0.44
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
ESR1 P03372 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
ESR2 Q92731 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27933355 0.87 CCR6 (0.53) MAPTTSHRTP53KDM4EALDH1A1
SCHEMBL28068481 0.85 TSHR (0.47) ALOX5MAPTTSHRTP53KDM4E
SCHEMBL28486252 0.81 SLC6A3 (0.57) EGFRMAPTTSHRKDM4EALDH1A1
SCHEMBL28335553 0.79 MAPK1 (0.56) MAPTTSHRTP53KDM4EALDH1A1
SCHEMBL28333205 0.78 ALDH1A1 (0.53) MAPTTP53KDM4EALDH1A1GAA
SCHEMBL28068265 0.78 ALDH1A1 (0.50) MAPTTSHRTP53KDM4EALDH1A1
Diethyl Phthalate SCHEMBL21811188 0.78 TSHR (0.75) MAPTTSHRKDM4EALDH1A1GAA
SCHEMBL28335530 0.78 ERN1 (0.51) MAPTTSHRKDM4EALDH1A1GAA
SCHEMBL28333214 0.78 KDM4E (0.47) MAPTTP53KDM4EALDH1A1GAA
SCHEMBL28333209 0.77 KDM4E (0.57) MAPTTSHRKDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105566110-B A kind of synthetic method of polysubstituted 1 naphthols and its derivative 南开大学 2017-10-20 CN disclosed
CN-105566110-A Synthesis method of polysubstituted 1-naphthol and derivatives thereof UNIV NANKAI 2016-05-11 CN disclosed