SCHEMBL28486252

SCHEMBL28486252

CCOC(=O)c1ccccc1-c1ccc(C(=O)OC)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 4/20 0.57
SLC6A4 P31645 3/20 0.57
TSHR P16473 2/20 0.57
SLC6A2 P23975 1/20 0.51
ERN1 O75460 1/20 0.51
ALDH1A1 P00352 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
SCN1A P35498 2/20 0.50
SCN2A Q99250 2/20 0.50
SCN3A Q9NY46 2/20 0.50
HSD17B10 Q99714 2/20 0.50
EGFR P00533 1/20 0.50
MEN1 O00255 1/20 0.50
NPC1 O15118 1/20 0.50
GAA P10253 1/20 0.50
RAB9A P51151 1/20 0.50
KMT2A Q03164 1/20 0.50
LTB4R2 Q9NPC1 1/20 0.48
PDK2 Q15119 1/20 0.48
KDM4E B2RXH2 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diethyl Phthalate SCHEMBL21811188 0.88 TSHR (0.75) TSHRALDH1A1SMN1; SMN2HSD17B10MEN1
SCHEMBL68818 0.88 SLC6A3 (0.73) SLC6A3SLC6A4TSHRSLC6A2ALDH1A1
SCHEMBL28485719 0.87 SLC6A3 (0.50) SLC6A3SLC6A4TSHRSLC6A2ALDH1A1
SCHEMBL3230316 0.84 TSHR (0.65) SLC6A3SLC6A4TSHRERN1ALDH1A1
SCHEMBL27686802 0.84 TSHR (0.65) SLC6A3SLC6A4TSHRERN1ALDH1A1
SCHEMBL29500171 0.84 TSHR (0.65) SLC6A3SLC6A4TSHRERN1ALDH1A1
SCHEMBL396552 0.84 TSHR (0.69) TSHRERN1ALDH1A1SMN1; SMN2SCN1A
SCHEMBL27435588 0.84 SLC6A3 (0.55) SLC6A3SLC6A4TSHRSLC6A2ALDH1A1
SCHEMBL5154594 0.84 ALDH1A1 (0.61) SLC6A3SLC6A4TSHRERN1ALDH1A1
SCHEMBL8606461 0.83 TSHR (0.62) SLC6A3SLC6A4TSHRERN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111807977-B 9-aniline fluorene-9-carboxylic ester compound and preparation method thereof 武汉理工大学 2022-11-04 CN disclosed
CN-111807977-A 9-aniline fluorene-9-carboxylic ester compound and preparation method thereof 武汉理工大学 2020-10-23 CN disclosed