Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17005427 | 1.00 | LMNA (0.46) | LMNAGRM5HRH4HRH3AGTR2 | |
| SCHEMBL3128357 | 1.00 | LMNA (0.46) | LMNAGRM5HRH4HRH3AGTR2 | |
| SCHEMBL16653935 | 0.87 | SMN1; SMN2 (0.45) | LMNAHRH4HRH3L3MBTL1PTPN1 | |
| SCHEMBL21801870 | 0.87 | SMN1; SMN2 (0.45) | LMNAHRH4HRH3L3MBTL1PTPN1 | |
| SCHEMBL19181699 | 0.87 | LMNA (0.44) | LMNAGRM5HRH4HRH3AGTR2 | |
| SCHEMBL23249940 | 0.87 | SMN1; SMN2 (0.45) | LMNAHRH4HRH3L3MBTL1PTPN1 | |
| SCHEMBL17188998 | 0.87 | LMNA (0.44) | LMNAGRM5HRH4HRH3AGTR2 | |
| SCHEMBL17005348 | 0.87 | LMNA (0.44) | LMNAGRM5HRH4HRH3AGTR2 | |
| SCHEMBL23249892 | 0.87 | SMN1; SMN2 (0.45) | LMNAHRH4HRH3L3MBTL1PTPN1 | |
| SCHEMBL3487774 | 0.87 | SMN1; SMN2 (0.45) | LMNAHRH4HRH3L3MBTL1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240644-A1 | MORPHOLINE DERIVATIVE | REN, AGTR1, AGTR2 | LMNA 1966/4885GRM5 926/4885HRH4 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.