Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 5/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | F11 | P03951 | 2/20 | 0.36 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KAT7 | O95251 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.35 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28069921 | 0.84 | CFD (0.42) | CFDKAT6AF11TPSB2PLAU | |
| SCHEMBL16396602 | 0.74 | CFD (0.63) | CFDF11TPSB2GRM5SUCNR1 | |
| SCHEMBL29957277 | 0.71 | KEAP1 (0.50) | LMNAMAPTHTTSMN1; SMN2TDP1 | |
| SCHEMBL6950315 | 0.71 | KEAP1 (0.50) | LMNAMAPTHTTSMN1; SMN2TDP1 | |
| SCHEMBL16397161 | 0.69 | CFD (0.78) | CFDF11TPSB2SUCNR1 | |
| SCHEMBL16397300 | 0.67 | CFD (0.59) | CFDF11TPSB2PLAUSUCNR1 | |
| SCHEMBL28069940 | 0.66 | CFD (0.68) | CFDF11TPSB2PLAUSUCNR1 | |
| SCHEMBL31457035 | 0.66 | TAAR1 (0.39) | — | |
| SCHEMBL3320901 | 0.65 | MAPT (0.51) | GRM5NPC1LMNAMAPTHTT | |
| SCHEMBL4688780 | 0.64 | FFAR1 (0.60) | KAT6ACNR1LMNAHTTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555766-A | Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof | NOVARTIS AG | 2016-05-04 | — | — | CN | disclosed |