Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 5/20 | 0.31 |
| ▸ | MAOA | P21397 | 4/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29801969 | 1.00 | OPRM1 (0.32) | OPRM1OPRK1OPRL1MAPTMAOB | |
| SCHEMBL5274311 | 0.97 | OPRM1 (0.33) | OPRM1OPRK1OPRL1MAPTMAOB | |
| SCHEMBL10928766 | 0.85 | OPRM1 (0.36) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL4775323 | 0.74 | NPC1 (0.34) | — | |
| SCHEMBL26908144 | 0.74 | OPRM1 (0.33) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL2327354 | 0.74 | OPRM1 (0.45) | OPRM1OPRK1OPRL1LMNAKMT2A | |
| SCHEMBL4666989 | 0.70 | CYP2C9 (0.33) | OPRM1OPRK1OPRL1MAPTBACE1 | |
| SCHEMBL7551055 | 0.70 | PNMT (0.39) | MAOBMAOAPNMTTAAR1 | |
| SCHEMBL5168618 | 0.70 | OPRM1 (0.31) | OPRM1OPRK1OPRL1MAPTMAOB | |
| SCHEMBL434296 | 0.70 | KMT2A (0.33) | OPRM1OPRK1OPRL1MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106480160-A | Method for manufacturing microorganism detection device, microorganism detection method, microorganism detection kit, and device | 郑兆珉 | 2017-03-08 | — | — | CN | claimed |
| CN-110496090-A | A kind of composition and its application in the skin care item that impaired skin is stayed up late in preparation reparation | HUNAN YUJIA COSMETICS PRODUCTION CO LTD | 2019-11-26 | — | — | CN | disclosed |
| CN-110494448-A | Medicinal combination comprising anti-LY75 antibody | BERLIN CHEMIE AG | 2019-11-22 | — | — | CN | disclosed |
| CN-108409694-B | Euphorbia ebiacteolata Hayata D and E are used as the purposes of miR-29a inhibitor and apoptosis of mesenchymal stem cell inhibitor | Zhejiang Yuan Kangrui Biological Technology Co., Ltd. (CN) | 2019-10-29 | — | — | CN | disclosed |
| CN-105582023-B | A kind of preparation method of toad cake extract and its sustained release pellet | 浙江中医药大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-110339368-A | The preparation method of the targeting polyethylene glycol carbonic ester maytansine prodrug micelle of reduction response | 苏州大学 | 2019-10-18 | — | — | CN | disclosed |
| CN-106581691-B | Reduction-responsive targeting polyethylene glycol-polycarbonate maytansine prodrug micelle, and preparation method and application thereof | 苏州大学 | 2019-09-10 | — | — | CN | disclosed |
| CN-110201068-A | The application of a kind of gram of sense relieving sore-throat composition or preparation in preparation prevention and treatment dengue fever medicine | 广州王老吉药业股份有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-110201160-A | The preparation method of zirconium metal organic framework compound | 广东医科大学 | 2019-09-06 | — | — | CN | disclosed |
| CN-110117546-A | A kind of naphthoquinone compound and its inflammatory applications in marine fungi source | 广州中医药大学(广州中医药研究院) | 2019-08-13 | — | — | CN | disclosed |
| CN-104689298-A | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage | ARAIM PHARMACEUTICALS INC | 2015-06-10 | — | — | CN | disclosed |
| CN-103509079-B | Ursolic acid derivative and preparation method thereof | UNIV PLA 3RD MILITARY MEDICAL | 2015-05-20 | — | — | CN | disclosed |
| CN-104619315-A | Synergistic pharmaceutical composition for treating lung cancer | COUNCIL SCIENT IND RES | 2015-05-13 | — | — | CN | disclosed |
| CN-104603189-A | Process for modifying a polymeric surface | POLYMERS CRC LTD | 2015-05-06 | — | — | CN | disclosed |
| CN-103396554-B | Hydrogel, preparation method thereof and applications | UNIV SOOCHOW | 2015-04-29 | — | — | CN | disclosed |
| CN-103305549-B | Genetic vector system of nanoparticle with multiple oxidation-reduction stimulus response as well as preparation method and application of genetic vector system | UNIV SICHUAN | 2015-04-22 | — | — | CN | disclosed |
| CN-104540506-A | Composition for preventing or treating eye diseases, containing s-allyl-l-cysteine as active ingredient, and pharmaceutical formulation containing same | PHARMAKING CO LTD | 2015-04-22 | — | — | CN | disclosed |
| CN-102066413-B | Tissue protective peptides and peptide analogs for the prevention and treatment of diseases and disorders associated with tissue damage | ARAIM PHARMACEUTICALS INC | 2015-01-21 | — | — | CN | disclosed |
| CN-102977014-B | New quinoline compounds and uses thereof | UNIV SHENYANG PHARMACEUTICAL | 2015-01-07 | — | — | CN | disclosed |
| CN-104211815-A | Ferritin heavy chain subunit nano medicament carrying system as well as preparation method and application thereof | UNIV EAST CHINA SCIENCE & TECH | 2014-12-17 | — | — | CN | disclosed |