Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 5/20 | 0.31 |
| ▸ | MAOA | P21397 | 4/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28070425 | 1.00 | OPRM1 (0.32) | OPRM1OPRK1OPRL1MAPTMAOB | |
| SCHEMBL5274311 | 0.97 | OPRM1 (0.33) | OPRM1OPRK1OPRL1MAPTMAOB | |
| SCHEMBL10928766 | 0.85 | OPRM1 (0.36) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL4775323 | 0.74 | NPC1 (0.34) | — | |
| SCHEMBL26908144 | 0.74 | OPRM1 (0.33) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL2327354 | 0.74 | OPRM1 (0.45) | OPRM1OPRK1OPRL1LMNAKMT2A | |
| SCHEMBL4666989 | 0.70 | CYP2C9 (0.33) | OPRM1OPRK1OPRL1MAPTBACE1 | |
| SCHEMBL7551055 | 0.70 | PNMT (0.39) | MAOBMAOAPNMTTAAR1 | |
| SCHEMBL5168618 | 0.70 | OPRM1 (0.31) | OPRM1OPRK1OPRL1MAPTMAOB | |
| SCHEMBL434296 | 0.70 | KMT2A (0.33) | OPRM1OPRK1OPRL1MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322099-A | Naproxen-cinnamic acid derivatives and application thereof in preparation of drugs for treating LPS (LPS) -induced inflammation | 五邑大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-114796112-A | Polymer nano micelle encapsulating two drugs and preparation method and application thereof | 四川大学华西医院 | 2022-07-29 | — | — | CN | disclosed |