Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28090827 | 0.88 | CYP17A1 (0.41) | CYP17A1PSMB8GAAPKMALOX15 | |
| SCHEMBL21199756 | 0.84 | GLS (0.40) | CYP17A1PSMB8GLSNPC1RAB9A | |
| SCHEMBL206754 | 0.79 | NFKB1 (0.50) | CYP17A1PSMB8GAAPKMALOX15 | |
| SCHEMBL15674780 | 0.78 | LMNA (0.42) | CYP17A1PSMB8GAAPKMALOX15 | |
| SCHEMBL10266596 | 0.78 | KDM4A (0.44) | GAACA1CA2GLSCA12 | |
| SCHEMBL28834445 | 0.78 | LCK (0.41) | CYP17A1PSMB8GAAPKMALOX15 | |
| SCHEMBL26991593 | 0.78 | LCK (0.42) | CYP17A1PSMB8GAAPKMALOX15 | |
| SCHEMBL21450366 | 0.78 | CA1 (0.42) | CYP17A1PSMB8GAAPKMALOX15 | |
| SCHEMBL1504066 | 0.78 | ATR (0.43) | CYP17A1PSMB8GAAPKMALOX15 | |
| SCHEMBL8704326 | 0.77 | HDAC3 (0.50) | ALOX15HSD17B10KCNQ4KCNQ5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658653-A | Furo- and thieno-pyridine carboxamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2016-06-08 | — | — | CN | disclosed |