Water

Water

SCHEMBL28070633

O.O=S(=O)(O)c1ccccc1.[KH].[KH]

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.89
SMN1; SMN2 Q16637 1/20 0.89
POLB P06746 1/20 0.58
CYP2D6 P10635 1/20 0.58
HTR6 P50406 1/20 0.52
LMNA P02545 1/20 0.52
ALDH1A1 P00352 4/20 0.50
NT5E P21589 1/20 0.50
TDP1 Q9NUW8 3/20 0.48
HSD17B10 Q99714 2/20 0.48
NAPRT Q6XQN6 1/20 0.48
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
MMP1 P03956 1/20 0.48
MMP2 P08253 1/20 0.48
MMP9 P14780 1/20 0.48
MMP8 P22894 1/20 0.48
MMP13 P45452 1/20 0.48
CA12 O43570 1/20 0.48
CA3 P07451 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27709309 1.00 TSHR (0.89) TSHRSMN1; SMN2POLBCYP2D6HTR6
Water SCHEMBL9064629 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Water SCHEMBL9212693 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Water SCHEMBL3932080 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Water SCHEMBL912228 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL2243698 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Water SCHEMBL338461 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
SCHEMBL132448 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Water SCHEMBL28988244 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6
Hydrogen Peroxide SCHEMBL28250789 0.97 TSHR (0.94) TSHRSMN1; SMN2POLBCYP2D6HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110607040-A High-strength environment-friendly recycled plastic particles 界首市圣通无纺布有限公司 2019-12-24 CN disclosed
CN-103562201-B Substituted benzazepines as modulators of TOLL-like receptors 帆德制药股份有限公司 2016-10-19 CN disclosed
CN-105669552-A Substituted benzoazepines as TOLL-like receptor modulators 文蒂雷克斯药品公司 2016-06-15 CN disclosed
CN-102781933-B Substituted benzazepines as modulators of TOLL-like receptors VENTIRX PHARMACEUTICALS, INC. (US) 2016-01-20 CN disclosed
CN-102781933-A Substituted benzazepines as modulators of TOLL-like receptors VENTIRX PHARMACEUTICALS INC 2012-11-14 CN disclosed