Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL27615970 | 0.89 | SLC22A6 (0.58) | LMNAEGLN1ALKBH5SUCNR1ABCC4 | |
| Adipic Acid SCHEMBL8986045 | 0.89 | LMNA (0.58) | LMNAABCC4MAPTTSHRNFKB1 | |
| Vinyl Ether SCHEMBL5669518 | 0.87 | CAMK2A (0.42) | LMNAEGLN1ALKBH5SUCNR1ABCC4 | |
| Butyric Acid SCHEMBL19138388 | 0.85 | FFAR3 (0.62) | LMNAMAPTOR51E2TSHRKMT2A | |
| Succinic Acid SCHEMBL28115947 | 0.84 | EGLN1 (0.38) | LMNAEGLN1ALKBH5SUCNR1ABCC4 | |
| Vinyl Ether SCHEMBL1226757 | 0.81 | — | — | |
| Vinyl Ether SCHEMBL29064322 | 0.80 | FFAR3 (0.56) | LMNAABCC4MAPTTSHRCYP2D6 | |
| Vinyl Ether SCHEMBL5600513 | 0.80 | GLRA1 (0.56) | LMNAABCC4MAPTOR51E2TSHR | |
| Succinic Acid SCHEMBL28172705 | 0.80 | EGLN1 (0.50) | LMNAEGLN1ALKBH5SUCNR1ABCC4 | |
| Vinyl Ether SCHEMBL28133322 | 0.78 | ALOX15 (0.41) | LMNAABCC4MAPTCYP2D6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105647633-A | Diester-type semisynthetic cutting fluid with high lubrication and high hard water resistance and preparation method thereof | 上海应用技术学院 | 2016-06-08 | — | — | CN | claimed |
| CN-105647633-A | Diester-type semisynthetic cutting fluid with high lubrication and high hard water resistance and preparation method thereof | 上海应用技术学院 | 2016-06-08 | — | — | CN | disclosed |