SCHEMBL2807223

SCHEMBL2807223

Cc1c(O)cccc1Sc1cccc(O)c1C

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.54
ATM Q13315 1/20 0.54
ALOX15 P16050 6/20 0.43
LMNA P02545 6/20 0.43
HSD17B10 Q99714 6/20 0.43
HPGD P15428 5/20 0.43
MAPT P10636 4/20 0.43
TP53 P04637 4/20 0.43
ALOX12 P18054 3/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
GAA P10253 1/20 0.43
THRB P10828 1/20 0.41
CA2 P00918 6/20 0.39
CA1 P00915 5/20 0.39
ALDH1A1 P00352 5/20 0.39
EGFR P00533 2/20 0.39
FYN P06241 2/20 0.39
MMP9 P14780 2/20 0.39
RECQL P46063 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2853747 0.85 SIRT1 (0.47) TRPA1ATMLMNAHPGDMAPT
SCHEMBL16320107 0.81 TRPA1 (0.50) TRPA1ATMALOX15LMNAHSD17B10
SCHEMBL4873527 0.78 TRPA1 (0.72) TRPA1ATMALOX15LMNAHSD17B10
SCHEMBL33721 0.78
SCHEMBL31604178 0.78 TRPA1 (0.46) TRPA1ATMALOX15LMNAHSD17B10
SCHEMBL29599714 0.77 ALOX15 (0.50) TRPA1ATMALOX15LMNAHSD17B10
SCHEMBL5150171 0.77 ALOX15 (0.50) TRPA1ATMALOX15LMNAHSD17B10
SCHEMBL2863653 0.76 TRPA1 (0.56) TRPA1ATMALOX15LMNAHSD17B10
SCHEMBL29085428 0.75 TRPA1 (0.68) TRPA1ATMALOX15LMNAHSD17B10
SCHEMBL30632314 0.75 TRPA1 (0.68) TRPA1ATMALOX15LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324675-A Naproxen derivative, preparation method thereof and application thereof in anti-breast cancer drugs 广州医科大学附属第五医院(广州再生医学与健康广东省实验室附属医院) 2024-07-12 CN claimed
CN-118324675-A Naproxen derivative, preparation method thereof and application thereof in anti-breast cancer drugs 广州医科大学附属第五医院(广州再生医学与健康广东省实验室附属医院) 2024-07-12 CN disclosed
CN-113597374-B Hollow resin particle for thermosensitive recording material 松本油脂制药株式会社 2023-06-27 CN disclosed
CN-115107391-A Thermosensitive recording medium, laser printing method and laser printing apparatus 株式会社理光 2022-09-27 CN disclosed
CN-112368154-B Drawing and erasing apparatus and erasing method 索尼公司 2022-09-13 CN disclosed
EP-2557105-B1 POLYCARBONATE RESIN, COMPOSITION OF SAID RESIN, AND MOLDED BODY OF SAID RESIN MITSUBISHI CHEM CORP (JP) 2014-12-10 EP disclosed
US-8569406-B2 Polycarbonate resin, composition of said resin, and molded article of said resin MITSUBISHI CHEMICAL CORPORATION (JP) 2013-10-29 US disclosed
EP-2557105-A1 POLYCARBONATE RESIN, COMPOSITION OF SAID RESIN, AND MOLDED BODY OF SAID RESIN Mitsubishi Chemical Corporation (JP) 2013-02-13 EP disclosed
US-20130030094-A1 POLYCARBONATE RESIN, COMPOSITION OF SAID RESIN, AND MOLDED ARTICLE OF SAID RESIN MITSUBISHI CHEMICAL CORPORATION (JP) 2013-01-31 US disclosed
US-8273273-B2 Manufacturing method for optical film KONICA MINOLTA OPTO, INC. (JP) 2012-09-25 US disclosed
US-20100239789-A1 Optical Film, Manufacturing Method for Optical Film, Polarizing Plate and Liquid Crystal Display Device KONICA MINOLTA OPTO, INC. (JP) 2010-09-23 US disclosed
US-20090169772-A1 RETARDATION FILM, METHOD FOR PRODUCING RETARDATION FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY KONICA MINOLTA OPTO, INC. (JP) 2009-07-02 US disclosed
US-5827590-A A PROTECTIVE LAYER COMPRISING BINDER, PIGMENT AND A CALCIUM ION TRAPPING AGENT WHICH TRAPS CALCIUM ION MIGRATION FROM DISPOSABLE NATURAL PAPER BACKING TO PROTECTIVE LAYER RICOH COMPANY, LTD. (JP) 1998-10-27 US disclosed
EP-0405843-B1 Molding material NIPPON ZEON CO (JP) 1995-04-05 EP disclosed
US-5143979-A Hydrogenated polymer formed by ring-opening polymerization of a norbornene-type polymer NIPPON ZEON CO., LTD (JP) 1992-09-01 US disclosed
EP-0405843-A2 Molding material NIPPON ZEON CO., LTD. (JP) 1991-01-02 EP disclosed