Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Paraquat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.56 |
| ▸ | QDPR | P09417 | 2/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paraquat SCHEMBL11565178 | 0.84 | SLC6A4 (0.56) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL4895671 | 0.83 | SLC6A4 (0.77) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| SCHEMBL14596518 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL11281521 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL4084640 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL9650240 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL8677067 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL21653 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL22370108 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR | |
| Paraquat SCHEMBL8331549 | 0.80 | SLC6A4 (0.72) | SLC6A4SLC22A2SLC22A1SLC22A3QDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105828610-A | Pesticidal compositions and methods related thereto | 美国陶氏益农公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105828608-A | Pesticidal Compositions And Related Methods | 美国陶氏益农公司 | 2016-08-03 | — | — | CN | disclosed |