Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 2/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16894177 | 0.82 | ABL1 (0.43) | TRPV3KDM4ETGFBR1ABL1BCR | |
| SCHEMBL25755088 | 0.79 | KIF11 (0.56) | TRPV3KIF11TGFBR1MAPKAPK2ABL1 | |
| SCHEMBL20224615 | 0.79 | CCR1 (0.53) | TRPA1TRPV3KDM4EABL1BCR | |
| SCHEMBL20224620 | 0.77 | RAD51 (0.41) | TRPA1TRPV3KDM4ETGFBR1HDAC1 | |
| SCHEMBL20224616 | 0.77 | NOS3 (0.47) | KIF11TGFBR1ABL1HDAC1BCR | |
| SCHEMBL20224612 | 0.76 | NOS3 (0.36) | TRPA1TRPV3KIF11TGFBR1HDAC1 | |
| SCHEMBL30636782 | 0.75 | CCR1 (0.48) | KDM4ETGFBR1MAPKAPK2PRKCAPLK1 | |
| SCHEMBL2521580 | 0.75 | CCR1 (0.48) | KDM4ETGFBR1MAPKAPK2PRKCAPLK1 | |
| SCHEMBL21022111 | 0.73 | TGFBR1 (0.48) | KDM4ETGFBR1MAPKAPK2 | |
| SCHEMBL17039389 | 0.73 | KIF11 (0.39) | TRPV3KIF11PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105612153-A | Substituted sulfonamide compounds as TRPA1 conditioner | HOFFMANN LA ROCHE | 2016-05-25 | — | — | CN | disclosed |