Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.57 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 6/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | THRB | P10828 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.74 |
| ▸ | PLG | P00747 | 1/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.63 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azelaic Acid SCHEMBL28549989 | 1.00 | TSHR (0.75) | TSHRLMNANFKB1PMP22KMT2A | |
| Glycine SCHEMBL28855970 | 1.00 | TSHR (0.75) | TSHRLMNANFKB1PMP22KMT2A | |
| Adipic Acid SCHEMBL15658059 | 0.97 | LMNA (0.73) | TSHRLMNANFKB1PMP22KMT2A | |
| Aminocaproic Acid SCHEMBL999851 | 0.92 | LMNA (0.90) | TSHRLMNANFKB1PMP22KMT2A | |
| Adipic Acid SCHEMBL541841 | 0.91 | NFKB1 (0.65) | TSHRLMNANFKB1PMP22KMT2A | |
| Sebacic Acid SCHEMBL27974435 | 0.88 | LMNA (0.83) | TSHRLMNANFKB1PMP22KMT2A | |
| Octanedioate SCHEMBL11875945 | 0.88 | LMNA (0.83) | TSHRLMNANFKB1PMP22KMT2A | |
| Azelaic Acid SCHEMBL11141213 | 0.88 | LMNA (0.83) | TSHRLMNANFKB1PMP22KMT2A | |
| Decanoic Acid SCHEMBL31288181 | 0.87 | GPR84 (0.81) | TSHRLMNAKMT2AALDH1A1MEN1 | |
| Sebacic Acid SCHEMBL23045133 | 0.87 | TSHR (0.86) | TSHRLMNANFKB1PMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108495646-A | For treating and/or the compound of nursing skin, hair, nail and/or mucous membrane | 路博润先进材料公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-105726387-A | Skin whitening microemulsion | 佛山市芊茹化妆品有限公司 | 2016-07-06 | — | — | CN | disclosed |