Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381513 | 0.86 | HMGCR (0.47) | HMGCRPOLBGGPS1GAAALDH1A1 | |
| SCHEMBL5664710 | 0.80 | HMGCR (0.57) | HMGCRPOLBGAA | |
| SCHEMBL2809486 | 0.80 | FDPS (0.42) | GGPS1TRPA1 | |
| SCHEMBL25922136 | 0.78 | HMGCR (0.56) | HMGCRPOLBGAAALDH1A1MAPT | |
| SCHEMBL5003858 | 0.76 | HMGCR (0.51) | HMGCRPOLBGAAALDH1A1LMNA | |
| SCHEMBL8589065 | 0.74 | HMGCR (0.49) | HMGCR | |
| SCHEMBL8170507 | 0.73 | HMGCR (0.55) | HMGCRPOLBGAAALDH1A1LMNA | |
| SCHEMBL5007391 | 0.72 | CA1 (0.54) | HMGCRALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL25922437 | 0.70 | HMGCR (0.53) | HMGCRPOLBGAAL3MBTL1 | |
| SCHEMBL5007372 | 0.70 | HMGCR (0.44) | HMGCRPOLBGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240612-A1 | Prenylated Bisphosphonates as Anti-tuberculosis Agents | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240612-A1 | Prenylated Bisphosphonates as Anti-tuberculosis Agents | GGPS1, FDPS, DCTPP1 | HMGCR 175/4885POLB 820/4885GGPS1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.