Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.54 |
| ▸ | CA1 | P00915 | 7/20 | 0.54 |
| ▸ | CA9 | Q16790 | 7/20 | 0.54 |
| ▸ | CA12 | O43570 | 6/20 | 0.54 |
| ▸ | ERN1 | O75460 | 2/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805285 | 0.89 | CA2 (0.61) | CA2CA1CA9CA12CA14 | |
| SCHEMBL30230622 | 0.89 | CA2 (0.61) | CA2CA1CA9CA12CA14 | |
| SCHEMBL30903622 | 0.88 | CA2 (0.69) | CA2CA1CA9CA12ERN1 | |
| SCHEMBL3720556 | 0.88 | CA2 (0.69) | CA2CA1CA9CA12ERN1 | |
| SCHEMBL3655412 | 0.85 | CAMKK2 (0.55) | CA2CA1CA9CA12ERN1 | |
| SCHEMBL31422694 | 0.83 | PARP1 (0.64) | ERN1PARP1CDK8DHODH | |
| SCHEMBL2431097 | 0.83 | PARP1 (0.64) | ERN1PARP1CDK8DHODH | |
| SCHEMBL6999225 | 0.81 | DHODH (0.63) | ERN1PARP1CDK8DHODH | |
| SCHEMBL28032548 | 0.81 | CA2 (0.73) | CA2CA1CA9CA12CA14 | |
| SCHEMBL13742952 | 0.81 | CA12 (0.81) | CA2CA1CA9CA12ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683157-B | Sulfonamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-105683157-A | Sulfonamides as modulators of sodium channels | 沃泰克斯药物股份有限公司 | 2016-06-15 | — | — | CN | disclosed |