Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.55 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 4/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397448 | 0.90 | GAA (0.55) | PARP1GAAVNN1ALDH1A1LMNA | |
| SCHEMBL29503163 | 0.90 | GAA (0.55) | PARP1GAAVNN1ALDH1A1LMNA | |
| SCHEMBL3727018 | 0.89 | PTGS2 (0.60) | CAMKK2ADAMTS4PARP1PTGS2ERN1 | |
| SCHEMBL28078713 | 0.85 | CA2 (0.54) | ADAMTS4PARP1ERN1GAACA12 | |
| SCHEMBL4252833 | 0.85 | KMO (0.59) | CAMKK2PTGS2GAAALDH1A1LMNA | |
| SCHEMBL31422694 | 0.82 | PARP1 (0.64) | PARP1ERN1DHODH | |
| SCHEMBL6243674 | 0.82 | KCNH2 (0.50) | PTGS2LOXL2 | |
| SCHEMBL2431097 | 0.82 | PARP1 (0.64) | PARP1ERN1DHODH | |
| SCHEMBL4581084 | 0.81 | CAMKK2 (0.48) | CAMKK2PARP1PTGS2VNN1FLT3 | |
| SCHEMBL13702345 | 0.81 | SMN1; SMN2 (0.54) | CAMKK2PTGS2GAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205556-A2 | BIARYL SULFONAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040289-A2 | BIARYL SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |
| US-20090088459-A1 | NOVEL BIARYL SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | US | disclosed |
| WO-2007067836-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088459-A1 | NOVEL BIARYL SULFONAMIDE DERIVATIVES | NR1H3, NR1H2, NR1H4 | CAMKK2 2239/4885ADAMTS4 4841/4885PARP1 4311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.