Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.96 |
| ▸ | HPGD | P15428 | 1/20 | 0.96 |
| ▸ | BLM | P54132 | 1/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.96 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirfenidone SCHEMBL4708 | 0.98 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL1006039 | 0.98 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL22492268 | 0.96 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL28532042 | 0.96 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL28115013 | 0.89 | KDM4E (0.83) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL27872362 | 0.89 | ALDH1A1 (0.83) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL356681 | 0.87 | ALDH1A1 (0.80) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL10059357 | 0.87 | KDM4E (0.79) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL3970272 | 0.85 | ALDH1A1 (0.77) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Deupirfenidone SCHEMBL4059454 | 0.85 | KDM4E (0.76) | KDM4EALDH1A1CYP1A2HPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112912386-A | Cell penetrating peptide based on influenza virus M2 protein | 中国医学科学院基础医学研究所 | 2021-06-04 | — | — | CN | claimed |
| CN-109010916-B | Moldable formulations containing oxysterol in acellular tissue matrices | 华沙整形外科股份有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-108786619-B | Bone material dispensing apparatus and method | 华沙整形外科股份有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-105517557-B | Bacterial strains having antimicrobial activity and biocontrol compositions comprising said strains | 特雷根控股有限公司 | 2021-11-30 | — | — | CN | disclosed |
| CN-110655585-A | Synthetic polypeptides and uses thereof | 中央研究院 | 2020-01-07 | — | — | CN | disclosed |
| CN-105793255-A | Heterocyclic compounds and their use | 无限药品股份有限公司 | 2016-07-20 | — | — | CN | disclosed |