Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirfenidone SCHEMBL1006039 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL22492268 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL28079090 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL28532042 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL28115013 | 0.91 | KDM4E (0.83) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL27872362 | 0.91 | ALDH1A1 (0.83) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL356681 | 0.89 | ALDH1A1 (0.80) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL10059357 | 0.89 | KDM4E (0.79) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL3970272 | 0.87 | ALDH1A1 (0.77) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Deupirfenidone SCHEMBL4059454 | 0.86 | KDM4E (0.76) | KDM4EALDH1A1CYP1A2HPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 20355 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4746852-A1 | LIPID AGGREGATES FOR INTRAARTICULAR ADMINISTRATION | Universität Bern (CH) | 2026-05-27 | — | — | EP | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| EP-4743067-A1 | PHARMACEUTICAL FORMULATIONS FOR INHALATION AND USES THEREOF | Insilico Medicine IP Limited (HK) | 2026-05-20 | — | — | EP | claimed |
| US-12622911-B2 | Methods and compositions for the treatment of pulmonary fibrosis using volasertib | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2026-05-12 | — | — | US | claimed |
| CN-122012505-A | Double-stranded oligonucleotide of targeted MMP-7 gene and application thereof | 北京阿尔纳科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-119528805-B | Pirfenidone eutectic crystal, preparation method thereof, pharmaceutical composition and application | 中山万汉制药有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12622899-B2 | Methods of treating idiopathic pulmonary fibrosis with deupirfenidone | PURETECH LYT 100, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12618855-B2 | Serum protein biomarker panel for idiopathic pulmonary fibrosis | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2026-05-05 | — | — | US | claimed |
| WO-1998014169-A1 | METHODS AND COMPOUNDS FOR TREATMENT OF ABNORMAL UTERINE BLEEDING | BRIGHAM & WOMEN'S HOSPITAL (US) | 1998-04-09 | — | — | WO | claimed |
| EP-0458861-B1 | COMPOSITION FOR REPARATION AND PREVENTION OF FIBROTIC LESIONS | MARGOLIN SOLOMON B (US) | 1996-04-03 | — | — | EP | claimed |
| US-5310562-A | 5-methyl-1-phenyl-2-(1H-) pyridone | INTERMUNE, INC. | 1994-05-10 | — | — | US | claimed |
| EP-0458861-A4 | COMPOSITION FOR REPARATION AND PREVENTION OF FIBROTIC LESIONS | — | 1992-07-08 | — | — | EP | claimed |
| EP-0458861-A1 | COMPOSITION FOR REPARATION AND PREVENTION OF FIBROTIC LESIONS. | MARGOLIN SOLOMON B (US) | 1991-12-04 | — | — | EP | claimed |
| WO-1990009176-A1 | COMPOSITION FOR REPARATION AND PREVENTION OF FIBROTIC LESIONS | MARGOLIN SOLOMON B (US) | 1990-08-23 | — | — | WO | claimed |
| EP-0383591-A2 | Use of 5-methyl-1-phenyl-2-(1H)-pyridone in the prevention and treatment of fibrotic lesions | Yamauchi, Shitotomo (JP) | 1990-08-22 | — | — | EP | claimed |
| US-4052509-A | 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1977-10-04 | — | — | US | claimed |
| US-4042699-A | 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1977-08-16 | — | — | US | claimed |
| US-3974281-A | ANALGESICS, ANTI-PYRETIC AND ANTI-INFLAMMATORY AGENTS | AFFILIATED MEDICAL RESEARCH, INC. (US) | 1976-08-10 | — | — | US | claimed |