Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pirfenidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | HPGD | P15428 | 1/20 | 0.83 |
| ▸ | BLM | P54132 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | COMT | P21964 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pirfenidone SCHEMBL1006039 | 0.91 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL4708 | 0.91 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL28532042 | 0.89 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL28079090 | 0.89 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL22492268 | 0.89 | KDM4E (0.96) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL27872362 | 0.83 | ALDH1A1 (0.83) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL356681 | 0.81 | ALDH1A1 (0.80) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL10059357 | 0.81 | KDM4E (0.79) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL12472372 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1CYP1A2HPGDBLM | |
| SCHEMBL10059326 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2HPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106491517-B | Preparation method of pirfenidone PVA hydrogel and pirfenidone PVA hydrogel | 佛山科学技术学院 | 2019-12-06 | — | — | CN | claimed |
| CN-106491517-A | The preparation method of pirfenidone PVA hydrogels and pirfenidone PVA hydrogels | 佛山科学技术学院 | 2017-03-15 | — | — | CN | claimed |
| CN-106491517-B | Preparation method of pirfenidone PVA hydrogel and pirfenidone PVA hydrogel | 佛山科学技术学院 | 2019-12-06 | — | — | CN | disclosed |
| CN-106491517-B | Preparation method of pirfenidone PVA hydrogel and pirfenidone PVA hydrogel | 佛山科学技术学院 | 2019-12-06 | — | — | CN | disclosed |
| CN-106491517-A | The preparation method of pirfenidone PVA hydrogels and pirfenidone PVA hydrogels | 佛山科学技术学院 | 2017-03-15 | — | — | CN | disclosed |
| CN-106491517-A | The preparation method of pirfenidone PVA hydrogels and pirfenidone PVA hydrogels | 佛山科学技术学院 | 2017-03-15 | — | — | CN | disclosed |