Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | HPGD | P15428 | 1/20 | 0.80 |
| ▸ | BLM | P54132 | 1/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.80 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RGS4 | P49798 | 1/20 | 0.38 |
| ▸ | RGS8 | P57771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970272 | 0.98 | ALDH1A1 (0.77) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL9892413 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| Hydronidone SCHEMBL143564 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL147877 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3307167 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3975362 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3302369 | 0.90 | ALDH1A1 (0.67) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL4708 | 0.89 | KDM4E (1.00) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL1006039 | 0.89 | KDM4E (1.00) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| Pirfenidone SCHEMBL22492268 | 0.87 | KDM4E (0.96) | ALDH1A1KDM4ECYP1A2HPGDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150368200-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. | 2015-12-24 | — | — | US | claimed |
| US-20150065720-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. | 2015-03-05 | — | — | US | claimed |
| US-20140221660-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2014-08-07 | — | — | US | claimed |
| US-20130345430-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2013-12-26 | — | — | US | claimed |
| EP-2440543-A2 | IMPROVED METHOD FOR SYNTHESIZING PIRFENIDONE | Intermune, Inc. (US) | 2012-04-18 | — | — | EP | claimed |
| US-20120016133-A1 | Method for Synthesizing Pirfenidone | INTERMUNE, INC. (US) | 2012-01-19 | — | — | US | claimed |
| US-20110003863-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2011-01-06 | — | — | US | claimed |
| WO-2010141600-A2 | IMPROVED METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2010-12-09 | — | — | WO | claimed |
| US-11066368-B2 | Process for the preparation and particle size reduction of pirfenidone | LAURUS LABS LIMITED (IN) | 2021-07-20 | — | — | US | disclosed |
| WO-2017130166-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF HIGHLY PURE ANTI-FIBROTIC DRUG | GRANULES INDIA LIMITED (IN) | 2017-08-03 | — | — | WO | disclosed |
| WO-2017122139-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF PIRFENIDONE | LAURUS LABS LIMITED (IN) | 2017-07-20 | — | — | WO | disclosed |
| US-20150368200-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20150368200-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20150368200-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20110003863-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-20110003863-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-20110003863-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| WO-2010141600-A2 | IMPROVED METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141600-A2 | IMPROVED METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141600-A2 | IMPROVED METHOD FOR SYNTHESIZING PIRFENIDONE | INTERMUNE, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066368-B2 | Process for the preparation and particle size reduction of pirfenidone | PIR, FIP1L1, RPLP1 | ALDH1A1 2893/4885KDM4E 1149/4885CYP1A2 1031/4885 |
| US-20120016133-A1 | Method for Synthesizing Pirfenidone | BRPF1, CYP2B6, CYP26B1 | ALDH1A1 138/4885KDM4E 587/4885CYP1A2 28/4885 |
| US-20150065720-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | BRPF1, CYP2B6, CYP26B1 | ALDH1A1 138/4885KDM4E 587/4885CYP1A2 28/4885 |
| US-20110003863-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | BRPF1, CYP2B6, CYP26B1 | ALDH1A1 137/4885KDM4E 937/4885CYP1A2 24/4885 |
| US-20150368200-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | BRPF1, CYP2B6, CYP26B1 | ALDH1A1 138/4885KDM4E 587/4885CYP1A2 28/4885 |
| US-20130345430-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | BRPF1, CYP2B6, CYP26B1 | ALDH1A1 138/4885KDM4E 587/4885CYP1A2 28/4885 |
| US-20140221660-A1 | METHOD FOR SYNTHESIZING PIRFENIDONE | BRPF1, CYP2B6, CYP26B1 | ALDH1A1 138/4885KDM4E 587/4885CYP1A2 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.