Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.60 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.60 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.45 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KDM5C | P41229 | 3/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.41 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL31697590 | 0.97 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Succinic Acid SCHEMBL7766385 | 0.97 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Succinic Acid SCHEMBL27874699 | 0.90 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Succinic Acid SCHEMBL7860504 | 0.90 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Glutarate SCHEMBL28859851 | 0.88 | SLC22A6 (0.65) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Adipic Acid SCHEMBL27739523 | 0.88 | LMNA (0.65) | LMNAGLAHSD17B10OR51E2SLC22A6 | |
| Levulinic Acid SCHEMBL27598664 | 0.87 | LMNA (0.70) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Succinic Acid SCHEMBL29029707 | 0.85 | EGLN1 (0.50) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Succinic Acid SCHEMBL9819357 | 0.85 | LMNA (0.50) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Adipic Acid SCHEMBL6429763 | 0.84 | LMNA (0.69) | LMNAHSD17B10OR51E2SLC22A6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110372642-A | Method for handling the compound based on homoserine | CJ第一制糖株式会社 | 2019-10-25 | — | — | CN | claimed |
| CN-117561248-A | Crystal forms of Ivoratinib and salts thereof, preparation method and application thereof | 杭州领业医药科技有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-105384728-B | Epoxy carboxylic acids' ester compounds and hardening thing containing its resin combination and the resin combination | 日本化药株式会社 | 2018-12-21 | — | — | CN | disclosed |
| CN-104520372-B | Polysaccharide slurries with environmentally friendly activator solvents | 罗地亚管理公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-106054526-A | ACTIVE ENERGY RAY CURABLE RESIN COMPOSITION WITH WHITE COLOR AND CURED PRODUCT THEREOF AND PRINTED WIRING BOARD | 日本化药株式会社 | 2016-10-26 | — | — | CN | disclosed |