Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 2/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL27874699 | 1.00 | LMNA (0.56) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL29029707 | 0.94 | EGLN1 (0.50) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL28079111 | 0.90 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Adipic Acid SCHEMBL28032942 | 0.88 | LMNA (0.61) | LMNAALDH1A1GLAOR51E2HSD17B10 | |
| Adipic Acid SCHEMBL1638937 | 0.88 | LMNA (0.61) | LMNAALDH1A1GLAOR51E2HSD17B10 | |
| Levulinic Acid SCHEMBL2634413 | 0.87 | LMNA (0.67) | LMNAEGLN1ALKBH5SUCNR1ALDH1A1 | |
| Succinic Acid SCHEMBL7766385 | 0.87 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Succinic Acid SCHEMBL31697590 | 0.87 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1GLA | |
| Tetrahydrofuran SCHEMBL8375806 | 0.86 | TSHR (0.63) | LMNAALDH1A1OR51E2HSD17B10SLC22A6 | |
| Tetrahydrofuran SCHEMBL8376666 | 0.86 | TSHR (0.63) | LMNAALDH1A1OR51E2HSD17B10SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109331019-B | Preparation method of composite trelagliptin succinate tablet | 安徽九华华源药业有限公司 | 2021-08-31 | — | — | CN | claimed |
| CN-111094290-A | Crystal form of mono succinate of Ribociclib, preparation method and application thereof | 苏州晶云药物科技股份有限公司 | 2020-05-01 | — | — | CN | claimed |
| CN-109331019-A | A kind of preparation method of compound amber love song Ge Lieting tablet | 深圳前海九华国际供应链管理有限公司 | 2019-02-15 | — | — | CN | claimed |
| JP-9020824-A | — | — | None | — | — | JP | disclosed |
| CN-111094290-B | Crystal form of mono succinate of Ribociclib, preparation method and application thereof | 苏州晶云药物科技股份有限公司 | 2022-06-17 | — | — | CN | disclosed |
| CN-114105948-A | Trelagliptin impurity compound | 鲁南制药集团股份有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-109331019-B | Preparation method of composite trelagliptin succinate tablet | 安徽九华华源药业有限公司 | 2021-08-31 | — | — | CN | disclosed |
| CN-111440145-A | Novel crystal form of high-purity trelagliptin and preparation method thereof | 上海医药工业研究院 | 2020-07-24 | — | — | CN | disclosed |
| CN-111094290-A | Crystal form of mono succinate of Ribociclib, preparation method and application thereof | 苏州晶云药物科技股份有限公司 | 2020-05-01 | — | — | CN | disclosed |
| CN-109331019-A | A kind of preparation method of compound amber love song Ge Lieting tablet | 深圳前海九华国际供应链管理有限公司 | 2019-02-15 | — | — | CN | disclosed |
| CN-102253094-B | Electromagnetic control electrode and preparation method thereof, and detection method of biological sample | UNIV PLA 3RD MILITARY MEDICAL | 2013-12-18 | — | — | CN | disclosed |
| CN-102702408-B | Preparation method of diene-based liquid rubber | PANJIN HEYUN NEW MATERIAL CO LTD | 2013-12-11 | — | — | CN | disclosed |
| CN-102702408-A | Preparation method of diene-based liquid rubber | LIAONING HEYUN SYNTHETIC RUBBER RES INST CO LTD | 2012-10-03 | — | — | CN | disclosed |
| CN-102253094-A | Electromagnetic control electrode and preparation method thereof, and detection method of biological sample | UNIV PLA 3RD MILITARY MEDICAL | 2011-11-23 | — | — | CN | disclosed |
| JP-2001122957-A | METHOD FOR CONTINUOUSLY PRODUCING POLYTETRAMETHYLENE ETHER GLYCOL DICARBOXYLATE | MITSUBISHI CHEMICALS CORP | 2001-05-08 | — | — | JP | disclosed |
| JP-H0920824-A | PRODUCTION OF POLY(TETRAMETHYLENE ETHER)GLYCOL | MITSUBISHI CHEM CORP | 1997-01-21 | — | — | JP | disclosed |