Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28461691 | 0.84 | MAPT (0.43) | CCR2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL28899797 | 0.77 | FBP1 (0.51) | KMT2A | |
| SCHEMBL28294933 | 0.74 | CCR2 (0.55) | CCR2APEX1CYP1A2MCL1KMT2A | |
| SCHEMBL3255649 | 0.74 | CCR2 (0.55) | CCR2APEX1KDM4EMCL1ALDH1A1 | |
| SCHEMBL27964872 | 0.74 | CCR2 (0.58) | CCR2APEX1MCL1KMT2AMEN1 | |
| SCHEMBL7993476 | 0.71 | CCR2 (0.64) | CCR2APEX1MAPTCYP1A2MCL1 | |
| SCHEMBL28079176 | 0.68 | CCR2 (0.54) | CCR2APEX1MAPTMCL1ALDH1A1 | |
| SCHEMBL16653775 | 0.67 | KDM4E (0.57) | KDM4EMAPTPKMCYP1A2CYP2C9 | |
| SCHEMBL5266320 | 0.65 | CCR2 (0.46) | CCR2APEX1KDM4EMAPTKMT2A | |
| SCHEMBL6141958 | 0.65 | HRH4 (0.43) | MAPTPKMCYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107098846-B | N-acyl sulfonamide FBPase inhibitor, preparation method thereof, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-10-09 | — | — | CN | disclosed |